Mycoplasmosis, an almost universal infection

According to the veterinary edition of the MSD Veterinary Manual, chronic respiratory disease in rats is caused mainly by a bacterium, Mycoplasma pulmonis, often together with other bacteria and viruses. Most pet rats are affected to some degree. The infection can stay quiet for a long time, then flare up and spread to the lungs.

It spreads through direct contact, through the air, during mating, and from mother to young at birth, according to the MSD Manual. The RVC adds that the infection lasts for the rat’s whole life.

“Red tears”: porphyrin, not blood

Behind each eye, rats have a gland, the Harderian gland, that produces a red pigment called porphyrin. According to the MSD Manual, it is secreted in larger amounts when the rat is stressed or ill: the tears turn red and dry into crusts around the eyes and nose that look like blood.

It isn’t a disease in itself but a signal: pain, acute stress or an underlying illness, often respiratory. RSPCA Australia advises having a rat with red tears checked promptly.

Bedding, ammonia and ventilation: what triggers flare-ups

According to the MSD Manual, how severe the disease becomes depends heavily on the level of ammonia in the cage, produced as urine breaks down, and on any other viruses or bacteria present. A lack of vitamin A or E also plays a part, according to the MSD Manual and the RVC.

  • Remove urine-soaked bedding every day, and change all the bedding at least twice a week, according to the MSD Manual.
  • Choose absorbent, low-dust paper bedding; avoid pine and cedar shavings and scented bedding.
  • No glass tanks or wooden cages: air circulates poorly or urine soaks into the wood, and ammonia builds up.
  • A well-ventilated cage, in a room kept at around 18 to 26 °C (64 to 79 °F), according to the MSD Manual.

Signs to watch for

  • Sneezing, snuffling, little clicking sounds when breathing.
  • Nasal discharge, red tears or red crusts around the eyes and nose.
  • Ruffled coat, hunched posture, tiredness, weight loss.
  • Head tilt: the infection can spread to the middle ear.

Separate a rat showing respiratory signs from its companions until you have your vet’s advice, as the MSD Manual for owners recommends.

What the vet does

Diagnosis is based mainly on the examination and the rat’s history; X-rays are sometimes useful. Treatment often combines several medicines given over several weeks: it relieves the signs without clearing the infection, and relapses are common.

According to the RVC, early, well-followed treatment gives the best chance, and many rats with chronic respiratory disease keep a good quality of life with the right care.

When it’s an emergency

With MyArk

Keep up a treatment that lasts weeks

Respiratory treatment often lasts for weeks, and relapses come back. In MyArk, every prescribed dose becomes a shared reminder: whoever gives the medicine ticks it off, and the whole household can see it’s done.

  • A reminder for every dose, on the schedule your vet prescribed
  • Respiratory episodes noted and dated in the health record
  • Weight followed in the weight tracker, to spot a relapse
  • A shared reminder for cleaning the bedding
Questions

Common questions

My rat is sneezing: is it serious?

An occasional sneeze isn’t necessarily worrying, but repeated sneezing, snuffling or discharge suggests a respiratory infection. See your vet early: prompt treatment gives better results.

Why does my rat have red around its eyes?

It is usually porphyrin, a red pigment made by a gland behind the eye, not blood. It increases with stress or illness: have your rat examined.

Can mycoplasmosis in rats be cured?

No: according to the MSD Veterinary Manual, treatment relieves the signs without clearing the bacterium. A good environment and early care help many rats live well with it.

Which bedding helps prevent respiratory problems in rats?

Absorbent, low-dust paper bedding. Avoid pine and cedar shavings and scented bedding, and remove urine-soaked areas every day to limit ammonia.

My rat makes little noises when it breathes: what should I do?

These little clicks or wheezes are among the respiratory signs vets describe. Book an appointment soon, and go straight away if its breathing becomes laboured or rapid.

Can a sick rat infect the others?

Yes: mycoplasmosis spreads through contact and through the air. The MSD Manual advises separating a rat with respiratory signs until you have your vet’s advice.

Sources

Benchmarks checked on 25 October 2026 in the documents below, then rewritten in plain English. They do not replace an examination and advice from your vet, who adapts care to your pet and to where you live.

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